1. If you were in Stan and Charmaine's situation, would you sign up for the Positron Project?
2. What is the significance of Charmaine's memories of Grandma Win and her cheerful aphorisms?
3. Do you think society could actually break down to the point that it does in the novel? Why or why not?
4. Bright colors figure into many descriptions in the novel, and act as a counterpoint to the drab quality of daily life in Positron. Stan and Charmaine's lockers are pink and green; the Alternates' lockers are purple and red; prison uniforms are orange; the knitted bears are blue. Do you think the colors assigned to the various objects are intentional or incidental?
5. How did your attitudes toward Stan and Charmaine change over the course of the novel?
6. The novel's title has surprising significance. When it was revealed, did you find it a clever twist or macabre and disturbing?
7. Charmaine is placed in an impossible situation when she discovers Stan on the gurney. Did she make the right choice? What would you have done?
8. No one is who he or she seems to be in Consilience. Did the shifting identities of characters make you wonder what their previous lives had been like before they came to Consilience? Would they have been better off "outside the walls"?
9. Could the Positron Project ever be a viable solution to solving societal upheaval?
10. The author is known for embracing emerging technologies, but in this work medical science and robotics are used in sinister and manipulative ways. In this sense is The Heart Goes Last a cautionary tale?
11. "The world is all before you," says Jocelyn at the close of the novel. How do you think Charmaine will adjust to freedom?